A Combination of Rosa Canina Extracts and Gold Complex Favors Apoptosis of Caco-2 Cells by Increasing Oxidative Stress and Mitochondrial Dysfunction
Identifieur interne : 000B49 ( Main/Exploration ); précédent : 000B48; suivant : 000B50A Combination of Rosa Canina Extracts and Gold Complex Favors Apoptosis of Caco-2 Cells by Increasing Oxidative Stress and Mitochondrial Dysfunction
Auteurs : Inés Mármol ; Nerea Jiménez-Moreno ; Carmen Ancín-Azpilicueta ; Jesús Osada [Espagne] ; Elena Cerrada [Espagne] ; María Jesús Rodríguez-Yoldi [Espagne]Source :
- Antioxidants [ 2076-3921 ] ; 2019.
Abstract
Given the alarming increase in colorectal cancer (CRC) worldwide, novel therapies are urgently needed. Plant-derived extracts have gained considerable interest in the last years due to their strong anticancer effect mediated by their unique bioactive compounds. Specifically, rosehips from
Url:
DOI: 10.3390/antiox9010017
PubMed: 31878141
PubMed Central: 7023183
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Combination of <italic>Rosa Canina</italic> Extracts and Gold Complex Favors Apoptosis of Caco-2 Cells by Increasing Oxidative Stress and Mitochondrial Dysfunction</title><author><name sortKey="Marmol, Ines" sort="Marmol, Ines" uniqKey="Marmol I" first="Inés" last="Mármol">Inés Mármol</name><affiliation><nlm:aff id="af1-antioxidants-09-00017">Department of Pharmacology and Physiology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain;<email>ines.marmol9@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Jimenez Moreno, Nerea" sort="Jimenez Moreno, Nerea" uniqKey="Jimenez Moreno N" first="Nerea" last="Jiménez-Moreno">Nerea Jiménez-Moreno</name><affiliation><nlm:aff id="af2-antioxidants-09-00017">Department of Science, Public University of Navarra, INAMAT, 31006 Pamplona, Spain;<email>nerea.jimenez@unavarra.es</email> (N.J.-M.);<email>ancin@unavarra.es</email> (C.A.-A.)</nlm:aff></affiliation></author><author><name sortKey="Ancin Azpilicueta, Carmen" sort="Ancin Azpilicueta, Carmen" uniqKey="Ancin Azpilicueta C" first="Carmen" last="Ancín-Azpilicueta">Carmen Ancín-Azpilicueta</name><affiliation><nlm:aff id="af2-antioxidants-09-00017">Department of Science, Public University of Navarra, INAMAT, 31006 Pamplona, Spain;<email>nerea.jimenez@unavarra.es</email> (N.J.-M.);<email>ancin@unavarra.es</email> (C.A.-A.)</nlm:aff></affiliation></author><author><name sortKey="Osada, Jesus" sort="Osada, Jesus" uniqKey="Osada J" first="Jesús" last="Osada">Jesús Osada</name><affiliation><nlm:aff id="af3-antioxidants-09-00017">Department of Biochemistry and Molecular Biology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain;<email>josada@unizar.es</email></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af4-antioxidants-09-00017">Centro de Investigación Biomédica en Red - Obesidad y Nutrición (CIBERobn) (ISCIII), IIS Aragón, IA2, 50009 Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red - Obesidad y Nutrición (CIBERobn) (ISCIII), IIS Aragón, IA2, 50009 Zaragoza</wicri:regionArea><placeName><region nuts="2" type="communauté">Aragon</region></placeName></affiliation></author><author><name sortKey="Cerrada, Elena" sort="Cerrada, Elena" uniqKey="Cerrada E" first="Elena" last="Cerrada">Elena Cerrada</name><affiliation wicri:level="2"><nlm:aff id="af5-antioxidants-09-00017">Department of Inorganic Chemistry, Sciences Faculty, University of Zaragoza, 50009 Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Inorganic Chemistry, Sciences Faculty, University of Zaragoza, 50009 Zaragoza</wicri:regionArea><placeName><region nuts="2" type="communauté">Aragon</region></placeName></affiliation></author><author><name sortKey="Rodriguez Yoldi, Maria Jesus" sort="Rodriguez Yoldi, Maria Jesus" uniqKey="Rodriguez Yoldi M" first="María Jesús" last="Rodríguez-Yoldi">María Jesús Rodríguez-Yoldi</name><affiliation><nlm:aff id="af1-antioxidants-09-00017">Department of Pharmacology and Physiology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain;<email>ines.marmol9@gmail.com</email></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af4-antioxidants-09-00017">Centro de Investigación Biomédica en Red - Obesidad y Nutrición (CIBERobn) (ISCIII), IIS Aragón, IA2, 50009 Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red - Obesidad y Nutrición (CIBERobn) (ISCIII), IIS Aragón, IA2, 50009 Zaragoza</wicri:regionArea><placeName><region nuts="2" type="communauté">Aragon</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31878141</idno><idno type="pmc">7023183</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023183</idno><idno type="RBID">PMC:7023183</idno><idno type="doi">10.3390/antiox9010017</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000410</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000410</idno><idno type="wicri:Area/Pmc/Curation">000410</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000410</idno><idno type="wicri:Area/Pmc/Checkpoint">000A72</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A72</idno><idno type="wicri:Area/Ncbi/Merge">000D73</idno><idno type="wicri:Area/Ncbi/Curation">000D73</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D73</idno><idno type="wicri:Area/Main/Merge">000B49</idno><idno type="wicri:Area/Main/Curation">000B49</idno><idno type="wicri:Area/Main/Exploration">000B49</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Combination of <italic>Rosa Canina</italic> Extracts and Gold Complex Favors Apoptosis of Caco-2 Cells by Increasing Oxidative Stress and Mitochondrial Dysfunction</title><author><name sortKey="Marmol, Ines" sort="Marmol, Ines" uniqKey="Marmol I" first="Inés" last="Mármol">Inés Mármol</name><affiliation><nlm:aff id="af1-antioxidants-09-00017">Department of Pharmacology and Physiology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain;<email>ines.marmol9@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Jimenez Moreno, Nerea" sort="Jimenez Moreno, Nerea" uniqKey="Jimenez Moreno N" first="Nerea" last="Jiménez-Moreno">Nerea Jiménez-Moreno</name><affiliation><nlm:aff id="af2-antioxidants-09-00017">Department of Science, Public University of Navarra, INAMAT, 31006 Pamplona, Spain;<email>nerea.jimenez@unavarra.es</email> (N.J.-M.);<email>ancin@unavarra.es</email> (C.A.-A.)</nlm:aff></affiliation></author><author><name sortKey="Ancin Azpilicueta, Carmen" sort="Ancin Azpilicueta, Carmen" uniqKey="Ancin Azpilicueta C" first="Carmen" last="Ancín-Azpilicueta">Carmen Ancín-Azpilicueta</name><affiliation><nlm:aff id="af2-antioxidants-09-00017">Department of Science, Public University of Navarra, INAMAT, 31006 Pamplona, Spain;<email>nerea.jimenez@unavarra.es</email> (N.J.-M.);<email>ancin@unavarra.es</email> (C.A.-A.)</nlm:aff></affiliation></author><author><name sortKey="Osada, Jesus" sort="Osada, Jesus" uniqKey="Osada J" first="Jesús" last="Osada">Jesús Osada</name><affiliation><nlm:aff id="af3-antioxidants-09-00017">Department of Biochemistry and Molecular Biology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain;<email>josada@unizar.es</email></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af4-antioxidants-09-00017">Centro de Investigación Biomédica en Red - Obesidad y Nutrición (CIBERobn) (ISCIII), IIS Aragón, IA2, 50009 Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red - Obesidad y Nutrición (CIBERobn) (ISCIII), IIS Aragón, IA2, 50009 Zaragoza</wicri:regionArea><placeName><region nuts="2" type="communauté">Aragon</region></placeName></affiliation></author><author><name sortKey="Cerrada, Elena" sort="Cerrada, Elena" uniqKey="Cerrada E" first="Elena" last="Cerrada">Elena Cerrada</name><affiliation wicri:level="2"><nlm:aff id="af5-antioxidants-09-00017">Department of Inorganic Chemistry, Sciences Faculty, University of Zaragoza, 50009 Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Inorganic Chemistry, Sciences Faculty, University of Zaragoza, 50009 Zaragoza</wicri:regionArea><placeName><region nuts="2" type="communauté">Aragon</region></placeName></affiliation></author><author><name sortKey="Rodriguez Yoldi, Maria Jesus" sort="Rodriguez Yoldi, Maria Jesus" uniqKey="Rodriguez Yoldi M" first="María Jesús" last="Rodríguez-Yoldi">María Jesús Rodríguez-Yoldi</name><affiliation><nlm:aff id="af1-antioxidants-09-00017">Department of Pharmacology and Physiology, Veterinary Faculty, University of Zaragoza, 50009 Zaragoza, Spain;<email>ines.marmol9@gmail.com</email></nlm:aff></affiliation><affiliation wicri:level="2"><nlm:aff id="af4-antioxidants-09-00017">Centro de Investigación Biomédica en Red - Obesidad y Nutrición (CIBERobn) (ISCIII), IIS Aragón, IA2, 50009 Zaragoza, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>Centro de Investigación Biomédica en Red - Obesidad y Nutrición (CIBERobn) (ISCIII), IIS Aragón, IA2, 50009 Zaragoza</wicri:regionArea><placeName><region nuts="2" type="communauté">Aragon</region></placeName></affiliation></author></analytic><series><title level="j">Antioxidants</title><idno type="eISSN">2076-3921</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Given the alarming increase in colorectal cancer (CRC) worldwide, novel therapies are urgently needed. Plant-derived extracts have gained considerable interest in the last years due to their strong anticancer effect mediated by their unique bioactive compounds. Specifically, rosehips from <italic>Rosa canina</italic> have been successfully tested against several cancer models, including colon cancer. Moreover, gold derivatives are a promising alternative to the current platinum-based drugs commonly used in CRC chemotherapy due to their lack of affinity for DNA. Herein we have investigated the antitumor potential of a drug combination made of acidic polyphenols extracted from <italic>R. canina</italic> and the gold complex (Au(C≡C-2-NC<sub>5</sub>H<sub>4</sub>) (PTA)) in Caco-2 cell line as a model of CRC. The combination triggered strong apoptosis mediated by a blockage of the autophagic flux, which might be a consequence of a reactive oxygen species (ROS) increase and mitochondrial dysfunctionality. Our results suggest that the clinical application of plant polyphenols might enhance the anticancer effect of metallodrugs and reduce drug exposure time and therefore its side effects.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zhang, P Y" uniqKey="Zhang P">P.Y. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ci, Y" uniqKey="Ci Y">Y. Ci</name></author><author><name sortKey="Qiao, J" uniqKey="Qiao J">J. Qiao</name></author><author><name sortKey="Han, M" uniqKey="Han M">M. Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Han, L" uniqKey="Han L">L. Han</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S. 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Germain</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Espagne</li></country><region><li>Aragon</li></region></list><tree><noCountry><name sortKey="Ancin Azpilicueta, Carmen" sort="Ancin Azpilicueta, Carmen" uniqKey="Ancin Azpilicueta C" first="Carmen" last="Ancín-Azpilicueta">Carmen Ancín-Azpilicueta</name><name sortKey="Jimenez Moreno, Nerea" sort="Jimenez Moreno, Nerea" uniqKey="Jimenez Moreno N" first="Nerea" last="Jiménez-Moreno">Nerea Jiménez-Moreno</name><name sortKey="Marmol, Ines" sort="Marmol, Ines" uniqKey="Marmol I" first="Inés" last="Mármol">Inés Mármol</name></noCountry><country name="Espagne"><region name="Aragon"><name sortKey="Osada, Jesus" sort="Osada, Jesus" uniqKey="Osada J" first="Jesús" last="Osada">Jesús Osada</name></region><name sortKey="Cerrada, Elena" sort="Cerrada, Elena" uniqKey="Cerrada E" first="Elena" last="Cerrada">Elena Cerrada</name><name sortKey="Rodriguez Yoldi, Maria Jesus" sort="Rodriguez Yoldi, Maria Jesus" uniqKey="Rodriguez Yoldi M" first="María Jesús" last="Rodríguez-Yoldi">María Jesús Rodríguez-Yoldi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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